Histamine and Antihistamine Substances

Histamine and antihistamine substances.

Effect of histamine strength and devices on skin prick test (SPT) response following antihistamine inhibition

Results Suppression of wheal responses was significant following antihistamine up to 20hr for both HPC and most allergens (15% to 70% wheal size in mm). 1mg/mL histamine appeared negative in some cases under suppression when the 6mg/mL histamine was positive. The lowered wheal size persisted in some subjects up to 72 hrs. Even though the HPC did not appear to be suppressed at some times followi...

The Effect of Histamine and Some Antihistamine in the Motility of Human Semin

The Effect of histamine and some Antihistamine in the motitlity of human semin were studid. It shows that the histamine increases sperm metility, further more H2 antihistamine crimetidine had no effect on sperm motility and classical antihistamines decreased sperm motility , where as the inhibition produced by H antihistamine could be over comed with increasing concentration of histamine. Final...

Synthesis and Characterization of Related Substances of Rupatadine Fumarate: an Antihistamine Drug

Rupatadine fumarate is a potent dual antagonist of histamine and platelet-activating factor antagonist (PAF antagonist) and used to treat allergies. During the process development of rupatadine fumarate, five related substances were observed in Rupatadine fumarate and one new related compound was observed during the stress oxidative degradation study. These related substances were identified as...

Suppressive effects of histamine skin reactivity by a nonsedating antihistamine-mequitazine.

The suppressive activity of mequitazine (MQZ) on histamine skin reactivity was evaluated in 29 healthy subjects (age 22-25 years) in a single-blind study. Fifteen subjects received MQZ, at a dosage of 5 mg BID, for 7 days while 14 served as controls. A prick skin test with saline or histamine hydrochloride (1 mg/ml and 10 mg/ml) was performed in duplicate, on both forearms, starting from the ba...